The MATRICS project aims to test applications for traceability and process automation in healthcare. Within the technological innovation project, two pilot actions will be developed employing RTLS (Real Time Location Services) technology for the containment of infection spread risk, obtaining as output a solution of absolute topicality and replicable and scalable potential in the field of hand hygiene compliance and indoor positioning & navigation for healthcare facilities. The method that the project partnership intends to develop in MATRICS will enable more effective control in contamination risk scenarios by evolving the current traditional/manual practice to a digitized system. The solution will be tested within a real operating environment (in a Lazio health facility). The proposal pursues the objective of increasing the competitiveness of the companies involved, through a process of improvement and innovation of production processes, business models and organizational models.