The project intends to create an integrated flow capable of responding to the needs related to customised prosthetics for large reconstructions of the musculoskeletal system: the development of an integrated solution capable of resolving technological, clinical, regulatory, psychological and organisational issues is the main objective. This is an ambitious project, since traditional prosthetics and regenerative medicine have not found effective, rapid and economical solutions: the unresolved problems cover various areas competing with the functional and social recovery of patients. The proposal, which will focus on additive technology and the development of solutions through 3D printing, aims to: increase the competitiveness of companies; innovate and improve production processes; generate new products; and promote possible new organisational models outside the partnership.